Figure 6.
Nucleosome and methylation maps as proxies for ancient gene expression. Relationship between three measures assessing gene expression. (A) Methylation ratio (Rs), a measure of methylation in promoter versus gene bodies. (B) First nucleosome occupancy, average read depth over the TSS +1 nucleosome region. (C) Phasing strength, a measure of strength of the periodicity between neighboring nucleosomes across the TSS region by Fourier transform analysis. All display a significant correlation with expression as measured by microarrays in modern hair follicles.
