Figure 5.
Unsupervised hierarchical clustering of tissue methylation profiles. Ms-based methylation levels of the Saqqaq individual are compared to the methylation profiles of five modern donors (PT1, PT2, PT3, PT4, and PT5) across four tissues (blood, buccal, saliva, and hair). Ms calculations were based on 2000-bp-wide genomic regions centered on each locus from the Illumina 450k array, disregarding those that showed less than 100 CpG sites at read starts (Supplemental Material SI3.4). The final set includes a total number of 7383 CpG sites.
