Figure 2.
PRC2 is recruited to the majority of active developmental enhancers. (A) The majority of PRC2 binding sites do not gain H3K27me3. Heatmap of a hierarchical clustering of Ezh2, Jarid2, H3K27me3, and H3K4me1 enrichment around the summits of Ezh2 and Jarid2 peaks. Data are visualized in 100-bp bins in 10-kb regions. (B) PRC2 is recruited to active enhancers. Enrichment of H3K4me1, RNAPII, H3K27me3, Ezh2, and Jarid2 at active enhancers. Data are visualized in 100-bp bins in 10-kb regions and are sorted by H3K4me1. Enhancers are defined as RNAPII peaks in regions with H3K4me1 but not H3K4me3.
