Mapping the distribution of regulatory activities along the genome. (A) Insertion of a regulatory sensor (drawing of sensor) at different distances from an enhancer (blue oval) and different positions relative to its target gene (blue arrow) can report on the domains of action of the enhancer. (B) A total of 734 insertions were characterized for expression in mid-gestation mouse embryos. About 55% of these reported regulatory activities. Insertions with (blue) or without (white) expression were broadly distributed around endogenous gene transcriptional start sites (distribution made with GREAT) (McLean et al. 2010). (C) Examples of the diverse expression patterns obtained in E11.5 embryonic forelimb (left) or forebrain (right). Numbers refer to insertion identifiers used in the TRACER database (Chen et al. 2013).
