Simultaneous identification and prioritization of variants in familial, de novo, and somatic genetic disorders with VariantMaster

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Figure 4.
Figure 4.

Performance of VariantMaster on the extraction of somatic variants from eight TCGA colorectal cancer matched tumor-germline samples in comparison with VarScan. VariantMaster yielded better results in all analyzed samples. In particular, VariantMaster achieved an average sensitivity of 72%, significantly higher than VarScan (55%). Moreover, VariantMaster outperformed VarScan in terms of precision, obtaining an average of 40% compared with 18% obtained by VarScan.

This Article

  1. Published in Advance January 3, 2014, doi: 10.1101/gr.163832.113 Genome Res. 24: 349-355

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