An integrated systems genetics screen reveals the transcriptional structure of inherited predisposition to metastatic disease

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Figure 5.
Figure 5.

Mir3470a and Mir3470b promote metastatic progression. (A) Stable transduction of Mir3470a and Mir3470b in 6DT1 cells. (B) Orthotopic implantation of 6DT1 cells overexpressing Mir3470a showed 40% increase in tumor mass (P = 0.014) and 230% increase in pulmonary metastasis (P = 0.0069). Overexpression of Mir3470b resulted in 213% increase in pulmonary metastasis (P = 0.088; ncontrol = 9 mice, nMir3470a = 10 mice, nMir-3470b = 10 mice). (C) Representative H&E stained lung sections from mice implanted with control or cells overexpressing Mir3470a/b. (*) P < 0.05, (**) P < 0.01.

This Article

  1. Published in Advance December 9, 2013, doi: 10.1101/gr.166223.113 Genome Res. 24: 227-240

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