Figure 6.
Interaction of CLL cells and the lymph node microenvironment. Stimulation of the BCR complex and other receptor and cell surface genes (CD79B, CD22, CD83, FCRG2B) leads to downstream changes in regulation. Affected genes such as those of the DUSP family, involved in the regulation of the MAPK pathway, may explain transcriptional differences observed for this pathway. Up-regulation of transcriptional regulators, like FOS and JUN, may trigger proliferation and inflammation processes that could be at the origin of C2 cells. Other genes involved in cell–cell signaling are also up-regulated in C2.
