Chimeric junctions between FCRL2–FCRL3 and GAB1–SMARCA5. (A) Schematic representation of the chimeric genes, associated ORFs, and junction sequences. (Top) Black boxes represent exons skipped by the chimeric junction. ORFs in the three possible frames are indicated in yellow. (Bottom) Sanger sequencing for the junction part of each chimera. The number in the square corresponds to the CLL sequenced sample. (B) Number of split-mapped (single reads split and mapped independently) and paired-end (two single reads from both ends of the same fragment) reads supporting the two chimeras and six previously described cases. TTTY15–USP9Y is reported twice because of the presence of two distinct fusion points. We should note that, although split-mapped and paired-end reads are shown separately, each chimera is supported by a combination of both.
