Figure 2.
HPV integration sites are clustered. HPV insertional breakpoints (dots), identified from discordant paired-end WGS reads, were mapped to human chromosomes (karyotypes, center). FISH and SKY images of chromosomes from various cancer cell lines (background colors, see key) are shown to the left and right of the karyotypes. Each set of FISH/SKY images includes (left) spectral karyotypes, (middle) chromosome banding patterns with HPV insertion sites (pink or teal fluorescent signals), and (right) pseudo-colored cartoons depicting chromosomal composition including translocations. The color key indicates the sample source. See also Supplemental Figures 5 and 6.
