TE-derived, cell type-specific TF binding peaks. (A) Venn diagrams represent the numbers of cell type-specific TE-derived binding events in human (top panel) and mouse (bottom panel). The numbers represent the total number of instances in which a TE-derived TF binding peak for a particular TF was found in one cell type but not in the other. (B) Comparison of the epigenetic profiles of TEs that contained TF binding peaks. These represent TEs that contained a TF binding peak for any TF in one cell line but not in the other. For comparison, we plotted the average epigenetic profile of TEs that contributed cell type-specific peaks in both cell types. (C) UCSC Genome Browser view of a lymphoblast-specific TE-derived (L1MB5) BHLHE40 binding peak that was conserved between human and mouse.
