Dynamic shifts in occupancy by TAL1 are guided by GATA factors and drive large-scale reprogramming of gene expression during hematopoiesis

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Figure 4.
Figure 4.

Histone modifications and chromatin states on TAL1 OSs. (A) Levels of five histone modification ChIP-seq signals (shown by box plots) in G1E, G1E-ER4 + E2, Ter119+ erythroblasts, and megakaryocytes were computed on the DNA segments occupied by TAL1 OSs in each cell type. (B) Chromatin states were determined using chromHMM (Ernst and Kellis 2010; Ernst et al. 2011) after learning the model from the five histone modifications in multiple cell types (Cheng et al. 2014). The pie chart shows the number of HPC-7-only TAL1 OSs that carry the designated pattern of chromatin states in the three erythroid cell types.

This Article

  1. Genome Res. 24: 1945-1962

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