Figure 4.
Inferred protein activity predicts survival in patients with Luminal A breast cancers (METABRIC). Using inferred protein activity, a prognostic signature for overall survival was trained on the METABRIC discovery set. Kaplan-Meier survival curves reveal higher- versus lower-risk patients on the validation set using inferred protein activity (top panels) but not the corresponding gene expression (bottom panels) using (A) univariate Cox models for PR, STAT5A, and HER2 and (B) multivariate Cox models.
