
Duplicates tolerate more nonsynonymous SNPs (NSNPs) than singletons. (A) A larger proportion of duplicates accumulate NSNPs (black portions) than singletons. (B) Most of the tolerance to NSNPs is found in duplicates originated by small-scale duplications (SSD), while those originated by whole-genome duplication (WGD) are not more enriched for NSNPs than are singletons when taking each duplicate as an independent gene.











