H3S28 phosphorylation is a hallmark of the transcriptional response to cellular stress

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Figure 2.
Figure 2.

Stress signaling via p38/MAPK mainly targets the regulators of signal transduction characterized by the high CG content of their promoters. (A) Changes in mRNA abundance of 21,608 RefSeq genes upon stress stimulation determined by full-length mRNA-seq. (B) Histogram showing the distribution of promoter classes according to CpG content. Weak and strong CpG promoters are enriched in the group of up-regulated genes (P-value = 1.052 × 10−14, χ2 test). (C) Transcription-factor motifs enriched in promoter regions (located between 400 bp upstream of and 100 bp downstream from the TSS) of up-regulated genes.

This Article

  1. Published in Advance August 18, 2014, doi: 10.1101/gr.176255.114 Genome Res. 24: 1808-1820

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