Figure 3.
PTPRZ1-MET likely confers unique function. (A) Fusion distribution of the Cancer Genome Atlas subtypes in the sGBM samples. The three ZM-fused sGBM samples consisted of one proneural and two classical subtypes. Due to the small sample size, ZM fusion did not show much association with IDH1 mutation. (B) Expression alteration in ZM-fused sGBMs compared with those without it. The former group showed higher expression of the MET-PIK3CA-AKT1 axis, as well as MDM2 and MDM4. (C) ZM-fused sGBM samples had a significantly shorter overall survival. (D) ZM-fused sGBM samples showed a higher proportion of MET overexpression and EGFR underexpression. (E) EGFR showed no prognostic value in the sGBM samples.
