C. elegans whole-genome sequencing reveals mutational signatures related to carcinogens and DNA repair deficiency

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Figure 7.
Figure 7.

Chromoanasynthesis in animals treated with crosslinking agents. (A) Copy-number profile and genomic rearrangements observed on chromosomes I, II, IV, and V for an xpf-1-deficient animal treated with cisplatin. (B) Copy-number profile and genomic rearrangements observed on chromosome X for a wild-type animal exposed to mechlorethamine. (C) Copy-number profile and genomic rearrangements observed on chromosomes V and X for another wild-type animal exposed to mechlorethamine.

This Article

  1. Published in Advance July 16, 2014, doi: 10.1101/gr.175547.114 Genome Res. 24: 1624-1636

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