T-cell receptor repertoires share a restricted set of public and abundant CDR3 sequences that are associated with self-related immunity

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Figure 2.
Figure 2.

Convergent recombination continuously increases as a function of sharing. (A) Convergent recombination of all CDR3 sequences as a function of sharing level. Each black dot represents the total number of nt sequences coding for the same CDR3 aa sequence (summed across all mice in which this sequence is found). The red dots show the mean value for each sharing category. The colored dots refer to the four sequences shown in B. (B) The frequencies of nt sequences that encode four selected CDR3 aa sequences: CASSLGGQNTLYF (purple, found in n = 28 mice); CASSLGGNQDTQYF (blue, n = 27); CASSDNANSDYT (orange, n = 7); and CGANRGLDTQYF (green, n = 3). Sequences are marked also in A and in Figure 1C. Each color in the bars of each panel represents a different nt sequence.

This Article

  1. Genome Res. 24: 1603-1612

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