Cotranscriptional histone H2B monoubiquitylation is tightly coupled with RNA polymerase II elongation rate

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Figure 7.
Figure 7.

Model depicting the coupling between H2Bub1 distribution within gene bodies and Pol II elongation rate. H2Bub1 distribution is highly coupled to Pol II elongation within transcribed regions. While H3K36me3 and H3K79me2 do not mirror Pol II kinetics at this time resolution, H2B is monoubiquitylated as Pol II progresses along the gene (A to B). Furthermore, Pol II pausing or a slower elongation rate at exons compared to flanking introns is coupled with lower H2Bub1 levels.

This Article

  1. Published in Advance July 21, 2014, doi: 10.1101/gr.176487.114 Genome Res. 24: 1572-1583

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