Figure 3.
Enrichment of ERBB2-amplification, BRCA1-loss, PHB-gain, and TP53-loss in breast cancer (n = 1174 breast cancers). Fold enrichments correspond to the ratio between observed and expected values, in which expected values were computed based on the individual frequencies of the four events examined (ERBB2 amplification, BRCA1 loss, PHB gain, and TP53 loss). P-values were derived empirically from 10 million shuffled data sets. (amp) Amplification (log2 copy number ratio > 1.0); (gain) copy number gain (log2 copy number ratio > 0.3); (loss) copy number loss (log2 copy number ratio < −0.3).
