Oncogenic organization of Chr 17 in breast cancer. (A) Chromosomal map of Chr 17, showing copy number state of the eight breast tumors analyzed, the frequency of copy number gain and loss across a combined data set of 1174 breast cancers, and the number of breast cancer prognosis-associated genes per 40-gene windows. Clusters of poor and good prognosis associated genes are located in copy number gain and loss regions, respectively. (B) Linear map of Chr 17, showing the frequency of copy number gain and loss as in A, as well as the copy number profile of three breast tumors and a breast cancer cell line, HCC2218, with information on recurrent unpaired inversions (below).
