KDM4C expression influences target gene expression levels. (A) Chromatin immunoprecipitation (ChIP) for KDM4C at target gene promoters in B cells from three individuals with high and three individuals with low KDM4C expression. The negative controls are the promoter of RPS6 and an intronic region. (B) The ratio of H3K9me2 to H3K9me3 at the eight target genes in A is shown for individuals with high KDM4C expression compared with low KDM4C expression (n = 3 per group). (C) Target gene expression levels in seven individuals with high KDM4C expression compared with seven individuals with low KDM4C expression, by qRT-PCR. RPS6 is used as the control gene. P < 0.05 for all target genes except RRP7A (t-test). Error bars, SEM.
