Functional DNA methylation differences between tissues, cell types, and across individuals discovered using the M&M algorithm

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Figure 7.
Figure 7.

Individual-specific DMRs. (A) Genomic distribution of individual-specific DMRs identified in blood (blue), breast (red), and fetal brain (green). (B) ChromHMM regulatory function annotation of individual-specific DMRs. (C) Histone modification profiles (H3K4me1 and H3K4me3) of individual-specific DMRs identified in fetal brain. (D) Human Epigenome Browser (Zhou et al. 2011) view of 30 juxtaposed individual DMRs identified in fetal brain with DNA methylation, H3K4me3, and H3K4me1 profiles. (E) Functional enrichment of individual-specific DMRs identified in fetal brain. (F) TFBS enrichment of individual-specific DMRs in fetal brain.

This Article

  1. Published in Advance June 26, 2013, doi: 10.1101/gr.156539.113 Genome Res. 23: 1522-1540

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