Functional DNA methylation differences between tissues, cell types, and across individuals discovered using the M&M algorithm

(Downloading may take up to 30 seconds. If the slide opens in your browser, select File -> Save As to save it.)

Click on image to view larger version.

Figure 6.
Figure 6.

Cell type-specific DMRs between CD4 naive cells and CD4 memory cells. (A) Genomic distribution of CD4 memory cell hypomethylated DMRs (green) and CD4 naive cell hypomethylated DMRs (red). (B) Histone modification profiles (H3K4me1 and H3K4me3) of DMRs between CD4 memory cells and CD4 naive cells. (C) Functional enrichment in CD4 memory cell (green) and CD4 naive cell hypomethylated DMRs (red). (D) ChromHMM regulatory function annotation of CD4 memory cell DMRs and CD4 naive cell DMRs. (E) TFBS enrichment of CD4 memory cell DMRs (green) and CD4 naive cell DMRs (red).

This Article

  1. Genome Res. 23: 1522-1540

Preprint Server