Functional DNA methylation differences between tissues, cell types, and across individuals discovered using the M&M algorithm

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Figure 5.
Figure 5.

Identification of tissue-specific DMRs spanning large chromosomal domains. (A) A breast-specific hypomethylated region containing multiple noncoding RNA genes. (Green box) ∼75-kb region hypomethylated in all breast cell types (luminal [Lum], myoepithelial [Myo], and stem cell-enriched [BSC]). (Red box) Hypermethylation events within the same region in the HCC1954 breast tumor cell line. (B) A large H1 ESC-specific hypermethylated chromosomal domain spanning the PCDHG gene cluster. (Orange box) H1 ESC-specific hypermethylated DMRs in the vicinity of the promoters of several PCDHG gene family members.

This Article

  1. Published in Advance June 26, 2013, doi: 10.1101/gr.156539.113 Genome Res. 23: 1522-1540

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