Next-generation sequencing of paired tyrosine kinase inhibitor-sensitive and -resistant EGFR mutant lung cancer cell lines identifies spectrum of DNA changes associated with drug resistance

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Figure 4.
Figure 4.

Pairwise comparison of samples. Identity-by-state (IBS) analysis was applied to compute the shared alleles for each pair of cell lines, with the mean on the x-axis and the variance on the y-axis. On the main panel, each point represents a pair of cell lines, regardless of whether they were matched (denoted by +) or not (denoted by a circle dot). In the internal panel, the truly matched sensitive-resistant pairs were enlarged to show the details.

This Article

  1. Published in Advance June 3, 2013, doi: 10.1101/gr.152322.112 Genome Res. 23: 1434-1445

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