Next-generation sequencing of paired tyrosine kinase inhibitor-sensitive and -resistant EGFR mutant lung cancer cell lines identifies spectrum of DNA changes associated with drug resistance

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Figure 3.
Figure 3.

Copy number variation (CNV) regions on chromosome 7 for HCC827/R1, HCC827/R2, and HCC4006/ER cells. (X-axis) Genomic position; (y-axis) log2 ratio of CNVs in resistant versus sensitive cells. Red lines indicate the segments. The size of the MET amplicon is different in HCC827/R1 and HCC827/R2 cells. See text for details.

This Article

  1. Published in Advance June 3, 2013, doi: 10.1101/gr.152322.112 Genome Res. 23: 1434-1445

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