Next-generation sequencing of paired tyrosine kinase inhibitor-sensitive and -resistant EGFR mutant lung cancer cell lines identifies spectrum of DNA changes associated with drug resistance

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Figure 2.
Figure 2.

Sanger sequencing chromatograms of mutations “lost” in drug-resistant cell lines compared with matched drug-sensitive cell lines. For each panel, the mutation marked by a red asterisk is shown in the sensitive line (top) and resistant line (bottom). (#) The mutation occurs in multiple transcripts with different nucleotide positions and/or amino acid positions. Detailed information is available in Table 4.

This Article

  1. Genome Res. 23: 1434-1445

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