Next-generation sequencing of paired tyrosine kinase inhibitor-sensitive and -resistant EGFR mutant lung cancer cell lines identifies spectrum of DNA changes associated with drug resistance

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Figure 1.
Figure 1.

Description of cell lines examined. (TKI) Tyrosine kinase inhibitor; (WGS) whole-genome sequencing; (WES) whole-exome sequencing. Cell lines in the left boxes are drug-sensitive, while those in the right boxes are drug-resistant. PC-9/S2, PC-9/ER, and PC-9/BRc1 were derived from PC-9/S1 cells; HCC827/R1 and HCC827/R2 were derived from HCC827 cells; HCC4006/ER were derived from HCC4006 cells. Comparisons between PC-9/S1 and PC-9/S2, PC-9/S1 and PC-9/ER, PC-9/S1 and PC-9/BRc1, HCC827 and HCC827/R1, HCC827 and HCC827/R2, and HCC4006 and HCC4006/ER were performed as detailed in the text.

This Article

  1. Published in Advance June 3, 2013, doi: 10.1101/gr.152322.112 Genome Res. 23: 1434-1445

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