Frequently altered cancer pathways in HCC. Core pathway analysis identified frequent genomic alterations in multiple cancer pathways, including (A) Wnt, (B) JAK/STAT, (C) G1/S cell cycle, and (D) apoptosis pathways. Alterations include somatic mutation, DNA copy number changes correlated with gene expression, and HBV integration. Alteration frequency was represented as a percentage of all cases harboring a genomic alteration in one of the pathway genes shown. Gene expression up- or down-regulation in tumor relative to normal samples is shown but not included in the calculation of alteration frequencies. Alteration types and frequencies were represented by different colors and color gradients, respectively.
