The complex SNP and CNV genetic architecture of the increased risk of congenital heart defects in Down syndrome

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Figure 1.
Figure 1.

Genome-wide Manhattan plots for CHD in DS and its different subphenotypes across 431,962 SNPs based on allelic associations. −log10 P-values of SNP association tests are plotted relative to their position on each chromosome (alternating black and gray). Chromosome 21 trisomic SNPs are not included here (for details, see text and Fig. 2). The results shown are for DS-CHD (A), DS-AVSD (B), DS-ASD (C), and DS-VSD (D).

This Article

  1. Published in Advance June 19, 2013, doi: 10.1101/gr.147991.112 Genome Res. 23: 1410-1421

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