Figure 4.
TF-binding regions initiate bidirectional transcription. Comparison of the enrichment of Pol II (Ser5), H3K4me3, and H3K4me1 at TSSs of ubiquitously expressed protein-coding genes (n = 4282) (A), and factor-specific TF-binding regions (n = 13,516) (B). Heat map rows are ranked by H3K4me3/H3K4me1 ratio and all signals plotted in 2-kb windows centered at (A) TIC mode TSSs, or (B) the midpoint of TF-binding regions. (C) Forward (red) and reverse (blue) TIC coverage plotted in a 2-kb region centered at the midpoints of factor-specific TF-binding regions; 60% of sites have both forward and reverse strand signals.
