Figure 6.
Key role of FOXA1 in prostate cancer cells (LNCaP). (Left) Most significant cooperativity predictions involving FOXA1 and underlying overrepresented motif complexes. The number of instances and P-value are given as in Figure 2. (Right) Predicted 3D structures of respective TF–TF–DNA complexes. (A) FOXA1–AR heterodimer; (B) diverging FOXA1 homodimer; (C) converging FOXA1 homodimer; (D) FOXA1–NFI heterodimer. Due to the lack of crystal structure for NFI in PDB, no 3D structure is predicted in D.
