Figure 5.
Rigidity and compactness of transcription factor dimers. (A) For each of the top 100 predictions, we display the motif complex enrichment P-value as a function of motif spacing (see Methods). Spacings to the left of the red line correspond to overlapping motifs. (B) Very few of the 603 predicted motif complexes remain significantly enriched when motif spacing is altered, suggesting that cooperative motif complexes are rigidly spaced. (C) Spacing distribution of predicted motif dimers (top) and known TF dimers (bottom; Supplemental Table 1). Spacings to the left of the red line correspond to overlapping motifs. Predicted and known dimers are compact, i.e., tightly spaced.
