Figure 6.
Distal regulatory sites can act as both enhancers and repressors in a tissue-dependent context. A model of tissue-specific gene regulation obtained via stable chromatin interactions. Bivalent promoters in embryonic stem cells are held in a poised, looped conformation with a distal site. Upon differentiation, the distal site is either activated by tissue-specific regulatory factors, leading to deposition H3K27ac and gene transcription, or repressed by recruitment of PRC2, as indicated by H3K27me3 marking.
