Major events in a decade of cancer genomics. (Dark blue) Major advances in massively parallel sequencing platforms and targeted enrichment technologies; (black) major large-scale projects designed to catalog genomic variations of normal human individuals; (red) cancer genomics. (dbSNP) Database of single nucleotide polymorphism; (HapMap) haplotype map of the human genome; (ENCODE) Encyclopedia of DNA Elements; (COSMIC) Catalog of Somatic Mutations in Cancer; (TCGA) The Cancer Genome Atlas; (GA) genome analyzer; (CRC) colorectal carcinoma; (WES) whole-exome sequencing; (ICGC) International Cancer Genome Consortium; (TSP) tumor sequencing project; (AML) acute myeloid leukemia; (WGS) whole-genome sequencing; (OSCC) ovarian small cell carcinoma.
