A dynamic H3K27ac signature identifies VEGFA-stimulated endothelial enhancers and requires EP300 activity

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Figure 6.
Figure 6.

VEGFA-increased gene expression and mediator binding associated with dynamic H3K27ac loci in H1 and H4-12 clusters. (A) Fold change of differentially expressed genes within 100 kb of dynamic H3K27ac loci belonging to the indicated clusters, compared to 0 h. Line, boxes, and whiskers are as in Fig. 5A,B. Notches are a function of the interquartile difference and inversely related to the square root of the sample size. (***) P < 0.0001, (**) P < 0.001. (NS) Not significant. (B) MED1 ChIP-qPCR of dynamic H3K27ac loci belonging to H1 or H4-12 clusters.

This Article

  1. Published in Advance April 1, 2013, doi: 10.1101/gr.149674.112 Genome Res. 23: 917-927

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