A revised model for Nab2 activity. This diagram depicts a subset of the proteins that we found to interact with Nab2 in an RNA-dependent or independent manner. We used our observations to expand on previous models of Nab2 function. Proteins separated by a black line (the RNA) with Nab2 had RNA-dependent interactions. When limited to well-studied proteins known to bind RNA, this RNA-dependent interaction data suggest that these RBPs bind to the same RNAs at the same time as Nab2. Proteins were placed in this diagram according to their known roles in RNA processing and regulation. Note that the RNA-independent interactions we detected between Nab2 and Mlp1 and Kap104 are also shown because of their known roles in Nab2 function.
