Patterns of regulatory activity across diverse human cell types predict tissue identity, transcription factor binding, and long-range interactions

(Downloading may take up to 30 seconds. If the slide opens in your browser, select File -> Save As to save it.)

Click on image to view larger version.

Figure 1.
Figure 1.

SOM clustering of DHS profiles. (A) A 50 × 50 self-organizing map (SOM). Each box represents a cluster of DHSs with similar DNase-seq signal profiles across samples, color-coded by tissue (legend, left). Cluster color corresponds to the combination of cell types in which the associated DHSs have high signal in the detailed profile. Square size indicates the number of DHSs assigned. (B) Average DHS profiles across samples for four individual clusters. Clusters contain sites open in highly related cell types (54 and 25) and less related cell types (1091 and 1295). (*) Malignant samples.

This Article

  1. Published in Advance March 12, 2013, doi: 10.1101/gr.152140.112 Genome Res. 23: 777-788

Preprint Server



Current Issue

  1. February 2026, 36 (2)
  1. Current Issue
  1. Alert me to new issues of Genome Research