Spatial congregation of STAT binding directs selective nuclear architecture during T-cell functional differentiation

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Figure 3.
Figure 3.

STAT4 knock-out T cells fail to develop Th1-specific Ifng interactome. (A,B) Examples of Ifng contacts in naive (green), Stat4 KO (pink), and Th1 (red) cells in trans (A) and cis (B). Stat4 KO cells fail to induce (A) or eliminate (B) specific contacts. (Arrows) Contact loci that are disrupted in KO versus WT Th1. (C) The overlaps between contacts from naive, Th1, and Th1-induced Stat4 KO. The areas are drawn in proportion to the numbers of probes in each category of overlaps.

This Article

  1. Published in Advance December 3, 2012, doi: 10.1101/gr.147652.112 Genome Res. 23: 462-472

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