DAXX-dependent supply of soluble (H3.3–H4) dimers to PML bodies pending deposition into chromatin

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Figure 1.
Figure 1.

Sequential targeting of epitope-tagged H3.3 to chromatin. (A) Intranuclear localization of H3.3-mC 24 h after transient transfection. (B) Intranuclear localization of H3.3-mC and H3.2-EGFP after cotransfection as in A. (C) Percentage of cells shown in A displaying indicated H3.3-mC distribution patterns over time after transfection (mean ± SD of three experiments, with more than 120 cells analyzed per experiments). (D) Time-lapse imaging of H3.3-mC starting 24 h after transfection (see Supplemental Movie 1). Scale bars, 10 μm.

This Article

  1. Published in Advance December 5, 2012, doi: 10.1101/gr.142703.112 Genome Res. 23: 440-451

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