Constitutive nuclear lamina–genome interactions are highly conserved and associated with A/T-rich sequence

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Figure 6.
Figure 6.

The core architecture is shared among lamin A and lamin B1. Genome–NL interaction profiles for mouse chromosome 2 as assayed by DamID of lamin A (A,D) and lamin B1 (B,E) in NPCs (A,B) and astrocytes (D,E). Data in B and E are from Peric-Hupkes et al. (2010). (Black) Constitutive regions; (gray) facultative regions. (C,F) Concordance scores are shown for all, constitutive (cLAD and ciLAD) and facultative regions.

This Article

  1. Published in Advance November 2, 2012, doi: 10.1101/gr.141028.112 Genome Res. 23: 270-280

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