Constitutive nuclear lamina–genome interactions are highly conserved and associated with A/T-rich sequence

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Figure 5.
Figure 5.

Correlation of A/T content with behavior of paralogous gene pairs. Panels show mean NL interaction scores in mouse ES cells for all known paralog pairs. Each dot represents a paralog pair, colored by percent difference in A/T content (A) and log2 difference in expression level (B). The assignment of paralog 1 or 2 is redundant, hence the symmetry across the diagonal. Expression data for mouse ES cells are taken from Mikkelsen et al. (2007), based on Affymetrix arrays, which is why for a number of genes no value is reported in B.

This Article

  1. Genome Res. 23: 270-280

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