Community-wide metrics suggest altered permissivity in niche specificity in colonization in PID individuals. Site codes: (Af) antecubital fossa; (N) nares; (Ra) retroauricular crease; (Vf) volar forearm. (A) Mean ± SEM for Shannon diversity is plotted for each patient group (colored as indicated) at all sites. (B) Site specificity is measured by the Yue-Clayton theta coefficient as in Figure 3, calculated between moist (antecubital fossa), dry (volar forearm), and sebaceous (retroauricular crease) skin sites and nares. (C) Longitudinal stability was assessed by calculating the theta coefficient between two and four timepoints for controls (light blue) and STAT3-HIES patients (red).
