The influence of genomic context on mutation patterns in the human genome inferred from rare variants

Regression results for recombination rate across variant subtype for rare variants, common variants, and substitutions. The relationship between local recombination rate (log₁₀ cM/Mb) and the observed conditional variant proportion for seven variant subtypes: (A) AT > GC, (B) AT > CG, (C) AT > TA, (D) CpG GC > AT, (E) GC > AT, (F) GC > TA, and (G) GC > CG (plotted as in Fig. 3). Filled points show the conditional variant proportions, scaled by the intercept of the logistic regression. Symbol size represents the proportion of the given variant subtype falling into a given recombination rate bin. The solid lines show the fitted logistic regression curve, where is the slope fitted in the logistic regression and is the recombination rate in the th bin. The gray dashed line represents the baseline of no effect, .