Tissue-specific alternative splicing within the human acyl-CoA synthetase long-chain family member 6 protein-coding gene. The GENCODE v16 annotation of ACSL6 contains 21 AS transcripts, two of which are shown here. The transcripts differ in the incorporation of distinct members of a mutually exclusive 78-bp cassette exon pair found in the same intron. Illumina Human BodyMap RNA-seq data read graphs are shown for five tissues (produced by Ensembl; see Fig. 4 legend for further details). Lymph, lung, and adrenal cells are seen to apparently utilize the upstream exon only, whereas liver cells show the opposite pattern. Brain cells appear to utilize either exon. Though apparently homologous, the exons differ at 30 out of 78 bp and 10 out of 26aa (not shown), which provides confidence that the read mapping has not been confounded by paralogy.
