Defining cell-type specificity at the transcriptional level in human disease

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Figure 2.
Figure 2.

In silico nanodissection. Distribution of cell-type–specific prediction by percentile, estimated using a Gaussian kernel. Genes are ordered on the x-axis from worst (zero percentile) to best (100th percentile). The dotted line shows in silico nanodissection cutoff for the top 136 genes. Nanodissection successfully separates (area under the curve [AUC] 0.83) podocyte-specific genes (green) from genes specific to other renal cell lineages (glomerular endothelial in dark blue, glomerular mesangial in light blue, and tubular in red).

This Article

  1. Genome Res. 23: 1862-1873

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