Estimating inbreeding coefficients from NGS data: Impact on genotype calling and allele frequency estimation

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Figure 2.
Figure 2.

Effect of the inbreeding coefficient on genotype calling. Performance of genotype calling globally (left column), on just heterozygous genotypes (center column) and just homozygous genotypes (right column), on a sample size of 10 (first row) and 30 (second row) individuals and 10,000 variable sites simulated with a 0.5% error rate. Line styles and symbols represent different simulated sequencing coverages. Line types represent the level of inbreeding assumed in the priors: F = 0 (HWE; filled) and inferred value of F (Infer. F; large dashes). Missing F = 1 values reflect the absence of heterozygous genotypes on a totally inbred sample.

This Article

  1. Genome Res. 23: 1852-1861

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