Figure 6.
Genomic location and architecture of EWSR1/FLI1 binding regions determine mode of target gene regulation. Two modes of EWSR1/FLI1-driven gene regulation: (A) Binding of EWSR1/FLI1 to distal ETS motifs in the absence of E2F binding results predominantly in target gene repression, while proximal cooperative promoter binding of EWSR1/FLI1 and EWSR1/FLI1 activated E2F3 results in target gene activation. (B) Spatial arrangement of ETS and E2F binding motifs in regions bound by EWSR1/FLI1 and E2F3.
