Figure 5.
Structure of the ribosome section corresponding to region orthologous to that of position 2617. (Left) The large ribosomal subunit from a bacterium, Deinococcus radiodurans, represented as ribbon. The A-, P-, and E-binding sites of tRNA on the ribosomal large subunit are shown. (Right) Sticks-and-ribbon representation of H71 and H64 interaction in the bacterial (blue) or human (yellow) orthologous ribosomes. The hydrogen bond that is disrupted by an adenine in position 2617 is represented as a dashed line. Numbers represent positions of E. coli ribosomal RNA.
