Bubble-seq analysis of the human genome reveals distinct chromatin-mediated mechanisms for regulating early- and late-firing origins

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Figure 3.
Figure 3.

Larger initiation zones replicate earlier on average and with less variable replication times than smaller zones. (A,B) Boxplots of SDs about TR50s as a function of S-phase window for all genomic EcoRI fragments (A), and for all bubble-containing fragments (B). (C) Boxplot of TR50s as a function of fragment number for isolated fragments (green) and zones (blue). (D) Boxplots of SDs about TR50s for all genomic isolated fragments (green) and for zones (blue) of increasing fragment numbers.

This Article

  1. Genome Res. 23: 1774-1788

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